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  5. Dissecting the molecular pathways of Glycogen Synthase Kinase-3 inhibition mediated self-renewal of

Dissecting the molecular pathways of Glycogen Synthase Kinase-3 inhibition mediated self-renewal of

来源 :第七届全国生物治疗大会 | 被引量 : 0次 | 上传用户：yh124712
【摘 要】
：
Background: CHIR99021, a GSK-3 specific inhibitor, promotes mouse and rat ESC self-renewal through inhibition of glycogen synthase kinase 3 (Gsk3) and subsequent negatively modulating Tcf3 via canonic
【作 者】
：
Ping Li Shou-dong Ye Chang Tong Qi-Long Ying 
【机 构】
：
Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC,Department of Ce
【出 处】
：
第七届全国生物治疗大会
【发表日期】
：
2014年3期
【关键词】
：
Embryonic stem cell Glycogen Synthase Kinase 3 (Gsk3) Self-renewal Tfcp211 
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　　Background: CHIR99021, a GSK-3 specific inhibitor, promotes mouse and rat ESC self-renewal through inhibition of glycogen synthase kinase 3 (Gsk3) and subsequent negatively modulating Tcf3 via canonical Wnt/(a)-catenin signaling.However, given the GSK3 is a multifunctional enzyme with a diverse number of actions in intracellular signaling systems, the mechanism of GSK3 inhibition promoted ESC self-renewal remains elusive.
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