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  5. The Impairment of CD4 + Cytotoxic T Cells Predicts Poor Survival and High Recurrence Rates in Patien

The Impairment of CD4 + Cytotoxic T Cells Predicts Poor Survival and High Recurrence Rates in Patien

来源 :中华医学会第十六次全国病毒性肝炎及肝病学术会议 | 被引量 : 0次 | 上传用户：kungfuchicken
【摘 要】
：
PURPOSE Although CD4 + cytotoxic T cells (CTLs) have been reported by several investigators, their significance in antitumor immunity in human cancer is unclear.This study aims to further characterize
【作 者】
：
Junliang Fu Lin Zhou Zheng Zhang Fu-Sheng Wang 
【机 构】
：
Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100083, China
【出 处】
：
中华医学会第十六次全国病毒性肝炎及肝病学术会议
【发表日期】
：
2013年7期
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PURPOSE Although CD4 + cytotoxic T cells (CTLs) have been reported by several investigators, their significance in antitumor immunity in human cancer is unclear.This study aims to further characterize CD4 + CTLs in hepatocellular carcinoma (HCC) patients, and to uncover the regulatory mechanisms by which they contribute to disease progression.Methods Five-hundred and forty-seven HCC patients, 46 liver cirrhosis (LC) patients, and 63 normal control individuals were enrolled.CD4 + CTLs were characterized by flow cytometry, immunohistochemistry and lyric granule exocytosis assays.Multivariate analysis of prognostic factors for overall survival was made using Coxs proportional hazards model.
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