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Background: Brain imaging plays an important role in the study of Alzheimers disease(AD),where metabolic disorder and atropy has been found to occur in the hippocampal formation during the very early disease stages and to progress in parallel with the diseases evolution.The aim of the present study was to evaluate a possible correlation between network properties and hippocampal metabolism in AD patients.Method: A dataset of 130 subjects,including 30 AD,50 MCI and 50 olderly controls was evaluated.Weighted and undirected networks were built by the Gretna pipeline using resting-bold data.The hippocampal metabolism was detected by multivoxel proton spectroscopy and the MRS data was processed by the Philips Achieva 3.0 T MR post-processing workstation.We compared the voxel-based degree of the whole brain and metabolic difference of hippocampus in three group.Further,we did correlation analysis between network properities and hippocampal metabolism.Results: Bilateral hippcampal metabolism were significant lower in MCI and AD compared to normal aging but showed no significant diffrerence between MCI and AD.Compared to MCI and NC,AD showed significant lower degree in many brain region such as bilateral hippocampus,bilateral parahippocampus,left amygdala,bilateral cingulate gyrus,bilateral entorhinal,bilateral preforntal lobe and bilateral insula.However,MCI just showed significant lower degree in left hippocampus and left amygdala compared to NC.Correaltion analysis revealed that hippocampal metabolism was significant positive related to the degree of brain region including bilateral hippocampus,left amagydala,left entorhinal and bilateral cingulate gyrus.Conclusion: Hippocampal metabolism disrupted in the progress of AD pathology and affect the network properities of some brain region mainly related to limbic system.It could represent a funtional counterpart of hippocampal metabolism and related network disconnection.