【摘 要】
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The majority of proteasome substrates identified so far are marked for degradation through polyubiquitinylation mediated by proteasome activator PA700 (aka
【机 构】
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InstituteofBiomedicalSciencesEastChinaNormalUniversityChina
【出 处】
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2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
The majority of proteasome substrates identified so far are marked for degradation through polyubiquitinylation mediated by proteasome activator PA700 (aka proteasome 19S).Exceptions to this principle are well-documented including proteasome-dependent,ubiquitin-independent protein degradation,such as by 11S proteasome activator (aka REG or PA28).REGγ (aka PSME3,PA28γ,or Ki antigen) is primarily located in the nucleus in a homoheptameric complex.It was traditionally believed that REG-γ only degrades peptides.We challenged this notion by providing the fih-st exciting evidence that REGγ is capable of targeting intact cellular proteins for proteasomal degradation (Li et al.Cell 2006; Li et al.Mol Cell 2007).Since our discovery of the biological targets of REGγ-proteasome,we and others have made substantial progress in understanding the functions of REGγ and its potential implication in important human diseases.
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