【摘 要】
：
Our hypothesis is that there is wear and tear in the brain, which is the basis of the process of aging, but that stimulation of brain function may slow down
【机 构】
：
DepartmentofNeurobiologyUniversityofAmsterdamTheNetherlands
论文部分内容阅读
Our hypothesis is that there is wear and tear in the brain, which is the basis of the process of aging, but that stimulation of brain function may slow down brain aging and diminish the risk for neurodegenerative diseases such as Alzheimers disease (AD), possibly by activating repair mechanisms.Evidence supporting this hypothesis is presented in this review.During normal aging and in AD, cell loss is not as prominent a phenomenon as is often presumed.In fact, unaltered neuronal numbers have been reported in many brain areas in AD, e.g.in the nucleus basalis of Meynert (NBM) where the number of large neurons decreases while that of small neurons increases.Decreased neuronal activity is an essential characteristic of AD, and a substantial decrease of cerebral glucose metabolism may even precede cognitive impairments.
其他文献
Age-associated cognitive decline, memory in particular, is a typical consequence of aging and an increasing biomedical concern, as over 38 million individua
伴着春风到来的全国人大和全国政协会议,沐着灿灿的阳光在北京落下了帷幕。 于蓝,这位连任6届的全国政协委员,带着过多的思索,又脚步匆匆地投入到紧张的工作之中。
Accompa
Neural stem cells (NSC) persist in the adult subependymal zone life-long and have the capacity to produce both olfactory bulb (OB) interneurons and oligoden
请下载后查看，本文暂不支持在线获取查看简介。
Please download to view, this article does not support online access to view profile.
核酸适配体是利用体外筛选技术,即指数富集的配体系统进化技术(SELEX),从核酸分子文库中得到的寡核苷酸片段.其与靶标物有很高的特异性和亲和力,将适配体作为识别单元的生物
The hypermethylation of CpG island is a frequent change in the occurrence of cervical cancer, which leads to the silence of tumor suppressor genes.Because D
Central nervous system (CNS) malformations in fetuses can be detected by ultrasound and/or MRI scans during pregnancy.In cases of termination of pregnancy o
We investigated how CNE2 cells react to DNA damage induced by ionizing radiation (IR) and whether genomic insult evokes DNA repair pathways and/or cell deat
Xihuang pill is created by Weide Wang, a physician of Qing dynasty.It is widely used in clinical for cancer treatment more than decades.Combining with chemo
保利房地产(集团)股份有限公司(下文简称保利地产)隶属于中国保利集团,是保利集团房地产业务的主要运作平台。保利地产1992年正式进入房地产行业,2002年完成股份制改造,作为