As a traditional national medication, Mongolian medication is evolved and developed through a long period medical practice.It not only has national and geographical characteristics, but also with unique theoretical system and clinical features.Mongolian drug has particular effect on anti-inflammation.However, the anti-inflammation mechanism of a variety of drugs is not clear due to limited modem science methodologies and techniques.In order to develop Mongolian anti-inflammation drug market and exploit its utilization,therefore, we urgently require finding out an innovative research strategy and methodology.Mitochondria, an important organelle for cellular energy transduction, and has been functionally linked to many kinds of metabolic and immunological diseases.From micro-systematic viewpoint, mitochondria are crucial factors for human physiological status.Therefore, digging into this factor through its interaction with the whole system, and also its response to external stimulation is always an important direction of research.And this theory is perfectly agreed with the Mongolian medication.Uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptor-γcoactivator-lα, PGC-lα) are two important functional effectors or indicators for mitochondria.In this study, the expression and activity of both UCP2 and PGC-1α were analyzed to evaluate the mitochondrial status and to check whether cells or tissues were normally functioning.Based on this study, a generalized research methodology for studying the physiologies and selective active ingredients of Mongolian anti-inflammation drugs is presented and proved.