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Successful vaccines targeting mucin-1(MUC1)provide an appealing approach for cancer immunotherapy.Herein,MUC1 glycopeptides,have been conjugated to bacteriophage Qβ virus-like particles and the immune responses to Qβ-MUC1 conjugates have been evaluated in both wildtype(Wt)mice and human mimic immunotolerant MUC1 transgenic(MUC1.Tg)mice.