【摘 要】
：
Herein we present the first global gene expression profile of a purified cancer stem cell (CSC) population.Constituting 0.08% of bone marrow cells,CD34+CD38-Thyl+ cells represent the CSCs in myelodysp
【机 构】
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Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Th
【出 处】
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2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
论文部分内容阅读
Herein we present the first global gene expression profile of a purified cancer stem cell (CSC) population.Constituting 0.08% of bone marrow cells,CD34+CD38-Thyl+ cells represent the CSCs in myelodysplastic syndromes (MDS) with an isolated deletion of the long arm of chromosome 5 (5q-syndrome).The gene expression pattern of5q-CD34+CD38-Thyl+ cells supports that 5q-stem cells originate in and outcompete normal CD34+CD38-Thyl+ stem cells.However,a few distinct differences in gene expression distinguish 5q-and normal CD34+CD38-Thyl+ stem cells.BMI 1,a critical regulator of self-renewal is up-regulated in 5q-stem cells,as is the myeloid transcription factor CEBP.These and other changes in gene expression are specific for 5q-CD34+CD38-Thy1+ stem cells,emphasizing the importance of specifically identifying,characterizing and eventually targeting CSCs.
其他文献
1 Institute of Biology,Leiden University,2 Microbial Physiology Research Group,University of Groningen,Kerklaan 30,9751 NN,Haren,The Netherlands,3 Section Fungal Genomics,Wageningen University,Dreijen
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