EETs mediated anti-oxidative stress effect on preventing vascular adventitial remodeling induced by

来源 :2014 International Symposium on Polyunsaturated Fatty Acids | 被引量 : 0次 | 上传用户：yunlong0451

【摘要】

：

　　Vascular adventitial remodeling is an important pathologic process in multiple vascular diseases.Reactive oxygen species (ROS) are an important triggering f

【作者】

：

Jun Xiong Chen Chao Jiang Xizhen Xu Chi Zhou Dao Wen Wang

【机构】

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DepartmentofInternalMedicineandInstituteofHypertension,TongjiHospital,TongjiMedicalCollege,HuazhongU

【出处】

：

2014 International Symposium on Polyunsaturated Fatty Acids

【发表日期】

：

2014年10期

【关键词】

：

Cytochrome P450 Eicosanoids Antioxidants Cell signaling Extracellular matrix adv

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　　Vascular adventitial remodeling is an important pathologic process in multiple vascular diseases.Reactive oxygen species (ROS) are an important triggering factor involved in this process.Herein, we investigated whether EETs could prevent the adventitial remodeling via reducing oxidative stress induced by angiotensin Ⅱ (Ang Ⅱ).C57BL/6J mice were treated with Ang Ⅱ by mini-pump to induce vascular remodeling after recombinant adeno-associated virus (rAAV)-mediated CYP2J2 overexpression.

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EETs mediated anti-oxidative stress effect on preventing vascular adventitial remodeling induced by

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