【摘 要】
：
Multi-drug resistant (MDR) bacteria present a significant,global healthcare problem that is amplified by the lack of new antibiotics,especially against MDR gram-negative pathogens.We developed new pha
【机 构】
：
Ordway Research Institute Albany,NY USA
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Multi-drug resistant (MDR) bacteria present a significant,global healthcare problem that is amplified by the lack of new antibiotics,especially against MDR gram-negative pathogens.We developed new pharmacokinetic/ pharmacodynamic models for antibiotics that link binding of antibiotics to their receptors with bacterial responses of multiple bacterial populations (e.g.susceptible and resistant).These models aim at 1) providing a quantitative understanding of the time-course of bacterial killing and mechanisms of synergy of antibiotic combinations against bacteria in specific phenotypic states,2) rationally optimizing antibiotic mono-and combination therapy,and 3) supporting a more efficient design and development of new antibiotics based on receptor binding.
其他文献
Cell lines are renewable and constitute an invaluable resource of central nervous system cell types for studies of news therapeutical agents against diseases of CNS.We have determined that flavonoids
For over three decades,controlled drug delivery by magnetic force,as exemplified by magnetic nanoparticles,has been of great interest,simply because it is relatively easy to apply a magnetic force ext
The main goal of the cancer research is to improve the clinical outcome of cancer patients.At present,we can perform tailor-made chemotherapy,the selection of effective chemotherapy based on evaluatio
CDC25 phosphatases are key actors in cyclin-dependent kinases activation whose role is essential at various stages of the cell cycle.CDC25 expression is upregulated in a number of human cancers.CDC25
Cigarette smoking is a major cause of lung cancer; however,it has been difficult to reproduce the tumorigenicity of cigarette smoke in preclinical animal models.Increased lung tumorigenicity has previ
Molecular targets for anti-cancer drugs have emerged from the accumulated evidence obtained by a huge number of the studies in oncology during more than recent three decades.These molecular-targeted a
Cancer is a complex disease resulting from perturbations in multiple regulatory intracellular systems leading to an overall increase in cell number and thus tumor formation.As cancer is a multifactori
Disordered lipid metabolism is always closely linked to inflammation.However,mechanisms of coordinate regulation of lipid metabolism and inflammation are unknown.Oxygenated cholesterols,oxysterols,app
In addition to P-glycoprotein/ABCB 1,for which third-generation inhibitors are in clinical development,two more-recently discovered ABC (ATP-binding cassette) transporters are critically involved in t
1.Nutritional concepts for treatment of chronic inflammatory diseases.Inflammation is defined as one of the first responses of the immune system to injury.When the injury is not eliminated,resolution