论文部分内容阅读
A study on the synthesis of anticancer drugs targeted mitochondrial
【机 构】
：
College of chemistry,Fuzhou University,Fuzhou city,350116
【出 处】
：
2015年全国药物化学学术会议暨第五届中英药物化学学术会议
【发表日期】
：
2015年3期
其他文献
Histone deacetylases(HDACs)are a family of enzymes that remove the acetyl groups of acetylated histones or other nonhistone substrates leading to transcriptional repression,and play important roles in
P-MMAE,a novel antibody-drug conjugate,is highly effective against primary HER2 overexpressing gastr
Gastric cancer is one of the most frequent human malignancies and the second leading cause of cancer-related death in the world.Human epidermal growth factor receptor 2(HER2)is overexpressed in~20%of
c-Met酪氨酸蛋白激酶是由Met原癌基因编码的一种细胞表面受体即肝细胞受体生长因子受体.HGF-Met信号通路的激活可促进肿瘤细胞生长、存活、迁移、侵袭及肿瘤血管的发生，并已经证实其信号失调与人肿瘤治疗的不良预后和耐药性密切相关.因此，靶向c-Met的小分子抑制剂是目前药物化学研究的热点.
Structure-Based Design and Synthesis of Novel Propane-1,3-diamino Bridged Derivatives as C-C Chemoki
Preventing of HIV entry into human host cells is an attractive way to controlling viral infection and replication,CCR5 is a coreceptor for entry of macrophage-tropic(R5)HIV-1 into host cells [1].
Senile Aβ plaques have been widely found in post-mortem brains of Alzheimers disease(AD)patients and are viewed as one of the principal hallmarks of the disease[1].A deposits are therefore thought to
As one of the most important members of the poly(ADP-ribose)polymerases(PARPs)families,PARP1 is a critical DNA repair enzyme in the base excision repair pathway.Inhibition of PARP1 is a potential "syn
Synthesis of multi-substituted 2-aminopyrroles/pyridines via chemoselective Michael addition/intramo
Multi-substituted pyrroles and pyridines are important scaffolds in medicinal chemistry and organic chemistry due to their prevalence in numerous natural products and synthetic compounds.
Chronic lymphocytic leukemia(CLL)remains the most incurable leukemia.Traditional chemotherapeutic treatments,including alkylating agents,purine nucleoside antagonists and immunotherapeutic antibodies,
Design and synthesis of 4-hydroxy-N1,N3-diphenyl-1,3-benzenedicarboxamide derivatives as potential a
In the last few years,a large structural variety of N-aryl-salicylamide derivatives as the potential EGFR PTK inhibitors have been synthesized and studied,which showed efficient antitumor activity1-5.