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Aim: To evaluate the association of PON1 genetic variants with the susceptibility to coronary artery disease (CAD) as well as clinical endpoints in aspirin and clopidogrel dualantiplatelet-treated Han Chinese patients with CAD after percutaneous coronary intervention (PCI).Methods: 538 Han Chinese patients undergoing PCI and received dual-antiplatelet therapy were sequentially recruited and followed up to 1 year.539 healthy controls were enrolled during the same period.The effect of 5 genetic variants in PON1 and CYP2C19*2 on the disease risk and clinical outcome of major adverse cardiac events (MACE) in 1 year or bleeding in 6 months was assessed.