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  5. Positive association of genetic variations in the phospholipase C-like 1 gene region with polymyosit

Positive association of genetic variations in the phospholipase C-like 1 gene region with polymyosit

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：true51
【摘 要】
：
Objective: PLCL1 (phospholipase C-like 1) encodes an inositol 1,4,5-trisphosphate (IP3) binding protein that can inhibit IP3 mediated calcium signaling.Yet the accurate mechanism by which PLCL1 played
【作 者】
：
Si Chen Qian Wang Yuan Li Ping Li Chan-Yuan Wu Zi-Yan Wu Qing-Jun Wu Fei Sun Jing Li Wei-Jie Zheng Chui-Wen Deng Feng-Chun Zhang Yong-Zhe Li 
【机 构】
：
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese A
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
【发表日期】
：
2014年8期
【关键词】
：
dermatomyositis polymyositis phospholipase C-like 1 gene polymorphism associatio 
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Objective: PLCL1 (phospholipase C-like 1) encodes an inositol 1,4,5-trisphosphate (IP3) binding protein that can inhibit IP3 mediated calcium signaling.Yet the accurate mechanism by which PLCL1 played in the pathogenesis of idiopathic inflammatory myopathies (IIMs) is unclear.One genome-wide association studies (GWAS) have designated PLCL1 as a potential risk factor for dermatomyositis (DM).In our study, we investigated whether PLCL1 polymorphisms could be associated with IIMs in Chinese Han.
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