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Varicella-zoster virus (VZV) is a human-restricted neurotropic alphaherpesvirus and invades the dermis and epidermis resulting in chicken pox.VZV infection induces both innate and antigen-specific immune responses.MHC-I is essential to present small peptides to the immune system which surveys for non-self peptides.Many viruses have evolved various strategies to disrupt the MHC-I antigen presentation pathway.