【摘 要】
：
Chemical investigation on the soft coral Sarcophyton sp.collected from the South China Sea yielded three new polyhydroxylated steroids,sarcophysteroids A–C (1–3),together with seven known ones (4–10).
【机 构】
：
Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean U
【出 处】
：
2013中国药学大会暨第十三届中国药师周
论文部分内容阅读
Chemical investigation on the soft coral Sarcophyton sp.collected from the South China Sea yielded three new polyhydroxylated steroids,sarcophysteroids A–C (1–3),together with seven known ones (4–10).Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related known compounds.All the isolates possessed the 3β,5α,6β-trihydroxylated steroidal nucleus.The cytotoxicities against selected HL-60,HeLa and K562 tumor cell lines and anti-H1N1 (Influenza A virus) activities for the isolates were evaluated.Compounds 2,3 and 5–8 exhibited potent activities against K562 cell lines with IC50 values ranging from 6.4 to 10.3 μM.Compounds 1,6–8 potently inhibited the growth of HL-60 tumor cell lines,and 6 also showed cytotoxicity towards HeLa cell lines.In addition,preliminary structure-activity relationships for the isolates were discussed.The OAc group at C-11 was proposed to be an important pharmacophore for their cytotoxicities in the 3β,5α,6β-triol steroids.Compounds 4 and 9 exhibited significant anti-H1N1 (influenza A virus,IAV) activities with IC50 values of 19.6 and 36.7 μg/mL,respectively.
其他文献
目的：建立HPLC库仑电化学方法测定四君子汤干预的脾虚大鼠不同脑区单胺类神经递质含量.方法：动物雄性SD大鼠,体质量180～200g,60只,由北京维通利华实验动物技术公司提供(SCXK(京)2002-0003).将60只大鼠分为空白对照组、脾虚组和四君子汤组,每组各20只.取大鼠,断头处死,迅速打开颅腔,取出全脑,在冰台上取双侧脑组织海马、下丘脑和纹状体,加1mL 0.4mol/LHClO4,在
心律失常多发生于有病心脏,心肌肥厚,电重构等构成心律失常基质,心肌离子通道功能异常而引起的心电紊乱直接诱发心律失常发生.分子生物学研究提示,所有通道蛋白的组装,变构,内质网均有参与,是离子通道发挥作用的上游.本课题研究内质网应激促心电异常发生机制.目的:本文探讨内质网应激促心电重构机制及药物干预.方法:大鼠40只,随机分为4组,每组10只.正常组皮下注射生理盐水,连续10天;模型组皮下注射异丙肾上
Aucklandia lappa Decne (A.lappa) was investigated the possible active compound(s) responsible for the butyrylcholinesterase (BChE) inhibitory effects and evaluated medicinal and therapeutic potentials
异戊烯基黄酮类化合物主要存在于豆科、桑科、芸香科等少数植物中,含量较低,且具有显著的多种生物活性,是药用植物活性物质的主要来源.天然存在的异戊烯基黄酮是通过Friedel-Crafts烷基化反应在各种类黄酮的母核上发生C5,C10或C15的异戊烯基取代及其后续的羟基化、环化等修饰反应.甘草是我国传统的中药材,具有调和诸药的作用,拥有数千年的使用历史,迄今为止已经从甘草中分离100余种异戊烯基黄酮类
贵州省黔东南州的凯里、黎平、榕江、从江等地区是苗族、侗族、瑶族等少数民族聚居地,且该地区又以其优越的自然条件孕育着丰富的芳香植物物种.本文借助弘治年间以来该地区的地方志,总结出了古代黔东南地区适宜生长的芳香植物物种,并对部分芳香植物从古至今的使用情况进行简略的探讨,如杉树、樟树、降香、藿香、茶油、春兰、依兰依兰、瑞香等.通过探讨总结出黔东南州芳香植物的发展概况,为该地区的芳香植物的开发利用提供一定
Metasequoia glyptostroboides Hu et Cheng is the only living species in the genus Metasequoia Miki ex Hu et Cheng (Taxodiaceae),which is well known as a “living fossil” species.In the Chinese folk medi
从红树内生真菌Penicillium dipodomyicola HN4-3A中分离得到一对结构新颖的苯并螺缩酮(1a和1b)对映异构体和3个新的结构类似物(2-4)以及2个已知的可能生源前体(5-6).利用NMR、MS、UV和IR等现代波谱分析方法对结构进行了鉴定,通过X-单晶衍射对上述新化合物(1-4)的结构进行了确证,并通过圆二色谱和量子化学计算确定了对映异构体1a和1b的绝对构型(Figu
目的：阐明南海软珊瑚Sarcophyton trocheliophorum的特征代谢产物.方法：以1H NMR和DAD-HPLC为导向,采用硅胶、ODS和半制备HPLC等色谱学方法,对中国南海软珊瑚Sarcophyton trocheliophorum中的萜类成分进行特征性分离,应用NMR,MS,IR等波谱学技术鉴定结构,并通过改良Mosher法、Mo2(AcO)4诱导CD法和X射线单晶衍射法确定
利用各种策略激活真菌沉默基因表达,拓展真菌产物多样性已成为当前研究热点.最近本课题组采用DMSO介导硫酸二乙酯诱变方法,成功改造了海洋来源无活性产紫青霉G59的遗传特性,获得了大量突变株,并对其中一株具有抗肿瘤活性突变株进行了产物研究,阐明了其沉默基因被激活而新产生的部分活性代谢产物,获得了结构新颖的活性化合物.为进一步探索DMSO介导硫酸二乙酯诱变对产紫青霉G59沉默基因激活能力,发现结构多样的
Chemical investigation of the aerial parts of mangrove plant Sonneratia Paracaseolaris yielded five new triterpenoids paracaseolins A-E (1-4,and 11) together with twelve known ones (5-10,12-17).Their