【摘 要】
：
Within the past ten years,pioneering studies in yeast,worms,flies and mice have revealed molecular pathways that regulate aging.Mutations in signal transduc
【机 构】
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University of Southern California, USA
【出 处】
：
2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
论文部分内容阅读
Within the past ten years,pioneering studies in yeast,worms,flies and mice have revealed molecular pathways that regulate aging.Mutations in signal transduction genes have increased life span of yeast and worms by up to five fold and have almost doubled the life span of mice.In yeast the down-regulation of glucose-dependent signaling by mutations in the RAS2,CYR1/PKA,or SCH9 genes extends the life span by up to 300% and increases resistance to oxidative stress and heat shock.Life span extension in yeast with reduced Ras2/PKA activity is mediated by stress resistance transcription factors Msn2 and Msn4 and mitochondrial superoxide dismutase (SOD2).In the worm Caenorhabditis elegans,the down-regulation of the IGF-I-like DAF-2 pathway,which includes AGE-1,AKT-1/AKT-2 and SGK-1 proteins extends survival by up to 300% and increases thermotolerance and antioxidant defenses,through the stress resistance transcription factor DAF-16.
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