【摘 要】
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The enzyme histidine decarboxylase (HDC), which generates histamine, is highly expressed in CDllb+Gr-1+ immature myeloid cells (IMCs) that play a critical role in infection, inflammation and tumorigen
【机 构】
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Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 20003
【出 处】
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The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会)
论文部分内容阅读
The enzyme histidine decarboxylase (HDC), which generates histamine, is highly expressed in CDllb+Gr-1+ immature myeloid cells (IMCs) that play a critical role in infection, inflammation and tumorigenesis.However, the role of IMC-derived histamine or HDC in atherogenesis remains poorly understood.Here, using HDC-EGFP bacterial artificial chromosome (BAC) transgenic reporter mice (HDC-EGFP), we demonstrate that HDC+ IMCs increase in the circulation in response to hypercholesterolemia and contribute to atherosclerosis.
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