【摘 要】
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Background,Motivation and Objective Neo-angiogenesis,resulting in the formation of an irregular network of microvessels,plays a fundamental role in the growth of several types of cancer.Characterizati
【机 构】
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Eindhoven University of Technology,Netherlands Un
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Background,Motivation and Objective Neo-angiogenesis,resulting in the formation of an irregular network of microvessels,plays a fundamental role in the growth of several types of cancer.Characterization of the microvascular architecture and blood flow has therefore gained increasing attention as a tool for cancer diagnosis,treatment monitoring,and test of new drugs.However,available techniques for assessment of the main features of the microvascular architecture,such as the microvascular density(MVD),require immunohistological analysis of the resected tumors.Nowadays,dynamic contrast-enhanced ultrasound imaging(DCE-US) provides new options for minimally invasive investigation of the microvasculature by analysis of ultrasound-contrast-agent(UCA) transport kinetics;features of the temporal and spatiotemporal evolution of the UCA concentration provide insight on perfusion,vascular fraction,and microvascular architecture.In this work,we propose a different method to analyze the UCA concentration that is based on the spatial distribution of blood flow.
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