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Backgroud& Aims:Chronic hepatitis C is both a virological and progressive fibrotic disease.Recent studies demonstrated that IL-22 and IL-20,cytokine expressed by immune cells and hepatocytes,respectively,both exacerbate liver fibrosis in patients with hepatitis C by activating hepatic stellate cells.The aims of this study were to evaluate whether IL-22 and IL-20 are related to disease progression and to explore the possible mechanisms.