Activation of AKT-AP1-FOXM1 signaling pathway confers sorafenib resistance to hepatocellular carcino

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：cchomonkey

【摘要】

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【作者】

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Xiaojing Yan Lingxi Chen Liangbo Sun Tao Li Fengtian He Jiqin Lian

【机构】

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Department of Biochemistry and Molecular Biology,Army Medical University,Chongqing,400038,China

【出处】

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中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

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2018年10期

【关键词】

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AKT AP1 FOXM1 HCC sorafenib resistance

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　　Sorafenib is the first-line drug for advanced hepatocellular carcinoma(HCC),but the clinical response to sorafenib is seriously limited by drug resistance.In this study,we investigated the molecular mechanisms of sorafenib resistance in HCC cells.Our data indicate that FoxM1 was significantly over-expressed in sorafenib-resistant cells,both at mRNA and protein levels.

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Activation of AKT-AP1-FOXM1 signaling pathway confers sorafenib resistance to hepatocellular carcino

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