【摘 要】
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Intraventricular adminstration of brain-derived neurotrophic factor(BDNF)can activate endogenous neural progenitor cells neurogenesis.However,it is difficult to be maintained at a sufficient concentra
【出 处】
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第一届辽宁省神经科学学会学术研讨会
论文部分内容阅读
Intraventricular adminstration of brain-derived neurotrophic factor(BDNF)can activate endogenous neural progenitor cells neurogenesis.However,it is difficult to be maintained at a sufficient concentration of BDNF in the hemorrhage hemisphere.It has demonstrated in our previous work that BDNF fused with a collagen-binding domain(CBD)could bind to collagen specifically.The ventricular ependyma of the brain is rich in collagen.Therefore,we have speculated that in the hemorrhage hemisphere,CBD-BDNF will bind to the collagen of the ventricular ependyma and stimulate the cell proliferation,differentiation in the subventricular zone(SVZ).
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