Targeting SUMO-specific Proteases Toward Discovery of New Anticancer Therapeutics

来源 :2013第六届世界癌症大会 | 被引量 : 0次 | 上传用户：hellen

【摘要】

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【作者】

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Huchen Zhou

【机构】

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School of Pharmacy, Shanghai Jiao Tong University China

【出处】

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2013第六届世界癌症大会

【发表日期】

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2013年12期

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　　As the best-characterized ubiquitin-like protein (UBL), small ubiquitin-related modifier (SUMO) was found to conjugate with a number of proteins to regulate cellular functions including transcription,signal transduction, and cell cycle.While El, E2 and E3 ligases are responsible for the forward SUMOylation reaction, SUMO-specific proteases (SENPs) reversibly remove SUMO from the SUMOylated proteins.Recently, SENP1 was found to be a potential therapeutic target for the treatment of prostate cancers.

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Targeting SUMO-specific Proteases Toward Discovery of New Anticancer Therapeutics

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