Preparations and characterizations of pH-sensitive Osthol-loaded Eudragit S100 Nanoparticles and an

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户:Melaniemei
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Objective: Osthol-loaded Eudragit S100 nanoparticle (Ost-S 100-NP) is a novel pH-sensitive nanparticle that are prepared with enteric material Eudragit S100.The preparation method, morphological characteristics,cellular uptake as well as its anti-tumor activity are also investigated in order to get a safe and effective formulation of Ost.
其他文献
Bone is a major organ of metastasis for many kinds of tumor, particularly for prostate and lung cancer.Although the bone metastasis of tumor is commonly not the major reason of death, symptoms associa
The applications of photodynamic therapy (PDT) were usually limited by low tumor selectivity of phtosensitizers.Herein, we reported an NIR imaging and mitochondria-targeted liposomes so called "theran
会议
Objective: Nowadays, RNA interference (RNAi) mediated by siRNA has rapidly become one of the standard tool for reversal of multidrug resistance.And the main difficulty of this is how to effectively im
Objective: To optimize the prescription of freeze-dried Alprostadil-loaded microemulsion and study the influences on entrapment efficiency of freeze-dried Alprostadil-loaded microemulsion.Methods: Bas
Poly (D, L-lactic-co-glycolic acid) microparticles (PLGA-MPs) loading macromolecule are widely used as a long-acting delivery syster.However, current preparation methods have many disadvantages to pre
会议
Mulberry alkaloid, extracted from Chinese Medicine Mulberry, is one potential oral medication for treating type 2 diabetes by inhibiting Glycosides.Its pharmacologic activity has been studied thorough
会议
Background: Nitinol stents are widely used as a palliative treatment for malignant dysphagia, but many stents become obstructed because of tumor ingrowth.A number of researchers have been working on d
会议
Redox-responsive drug delivery system based on the difference redox environments between extra-and intra-cellular (100-1000 folds) and the same as the tumor cells and normal cells(7-10 folds),which ma
Combination cancer therapy has attracted considerable attention due to its advantages of enhancing antitumor efficacy by generating synergistic effects and reducing toxicity over monotherapy.The appli
Carvedilol is an anti-hypertensive agent with nonselective β-blocking and α1-blocking activities.It has been widely used in the treatment of hypertension, myocardial infarction and congestive heart fa