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白细胞与内皮细胞的粘附与过度聚集是造成炎症反应的主要原因,特殊糖链结构介导了这种粘附过程.利用糖类分子抑制这一过程已成为发展抗炎药物的新策略.研究表明[1],四价乳糖簇Gu-4 分子在抗炎领域显示出了良好的活性,能显著抑制烧伤休克、类风湿性关节炎、感染性休克、脓毒血症等炎症.
抗粘附、抗炎候选分子Gu-4光亲和探针设计合成与靶点研究
【摘 要】
：
白细胞与内皮细胞的粘附与过度聚集是造成炎症反应的主要原因,特殊糖链结构介导了这种粘附过程.利用糖类分子抑制这一过程已成为发展抗炎药物的新策略.研究表明[1],四价乳糖
【机 构】
：
北京大学药学院化学生物学系天然药物与仿生药物国家重点实验室北京100191
【出 处】
：
第二届糖合成化学青年学术研讨会
【发表日期】
：
2017年5期
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