To investigate the effects of endosulfan on coagulation status and its mechanism, 32male wistar rats were randomly divided into four groups including a control solution and three concentrations of endosuifan groups (1, 5, 10 mg/kg/day).Results showed that endosulfan significantly promoted platelet aggregation, prolonged thrombin time and increased D-dimer level,decreased fibrinogen level; promoted the expressions of Fas, caspase-8, caspase-3 in vascular endothelial cell.The resulted suggested that endosulfan could cause hypercoagulability of blood by promoting both platelet aggregation and transformation of fibrinogen into fibrin.Endosulfan could induce the endothelial cells dysfunction resulting from oxidative stress.