The drug delivery systems with multiple functionalities integrated in one platform have drawn much attention in recent years.[1] In this study,a smart drug delivery system was designed based on methotrexate decorated magnetoliposomes(MTX-MLs)for folate receptor targeted/magnetic guided and magnetic hyperthermia/photothermal combined therapy.In this system,lipotropy fluorescent dye Cy5.5 and oleic acid modified magnetic nanoparticles(MNPs)were encapsulated into the bilayer of liposomes,followed by conjugation with MTX for tumor targeting.