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  5. Aldosterone metabolism and nonsteroidal anti-inflammatory drugs (NSAIDs): A link to increased cardio

Aldosterone metabolism and nonsteroidal anti-inflammatory drugs (NSAIDs): A link to increased cardio

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：parrotxu
【摘 要】
：
Considerable evidence exists that use of non-selective (eg, diclofenac) and cyclooxygenase (COX)-2 selective (eg, celecoxib) NSAIDs is associated with increased cardiovascular (CV) risk.Although the m
【作 者】
：
Kathleen M KNIGHTS 
【机 构】
：
Department of Clinical Pharmacology,School of Medicine,Flinders University,Adelaide,South Australia,
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
aldosterone metabolism NSAIDs cardiovascular risk 
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Considerable evidence exists that use of non-selective (eg, diclofenac) and cyclooxygenase (COX)-2 selective (eg, celecoxib) NSAIDs is associated with increased cardiovascular (CV) risk.Although the mechanism of the increased CV risk associated with NSAIDs is incompletely understood the prevailing view is that the inhibitory selectivity of NSAIDs towards COX-1 and COX-2 accounts for the CV toxicity.
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