【摘 要】
：
The lysosomal degradation pathway, autophagy, is essential for the maintenance of cellular homeostasis.Recently, autophagy has been demonstrated to be requi
【机 构】
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Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseas
【出 处】
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The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
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The lysosomal degradation pathway, autophagy, is essential for the maintenance of cellular homeostasis.Recently, autophagy has been demonstrated to be required in the process of adipocyte conversion.However, its role in mature adipocytes under physiological and pathological conditions remains unclear.Here, we report a major function of BECN1 in the regulation of basal autophagy in mature adipocytes.We also show that berberine, a natural plant alkaloid, inhibits basal autophagy in adipocytes and adipose tissue of mice fed a high-fat diet via downregulation of BECN1 expression.We further demonstrate that berberine has a pronounced effect on the stability of Becn1 mRNA through the Mir30 family.These findings explore the potential of BECN1 as a key molecule and a drug target for regulating autophagy in mature adipocytes.
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