【摘 要】
：
Carbonic anhydrase (CA) inhibitors have been proposed as a new class of antitumor agents.The expression of CA Ⅸ, VEGF and the activity of caspase-3 were evaluated in human renal cell carcinoma biopsie
【机 构】
：
University of Florence Italy
论文部分内容阅读
Carbonic anhydrase (CA) inhibitors have been proposed as a new class of antitumor agents.The expression of CA Ⅸ, VEGF and the activity of caspase-3 were evaluated in human renal cell carcinoma biopsies; moreover plasma concentration and activity of CA in healthy subjects and patients with benign and renal cell carcinoma were assessed.The antitumor activity of three CA inhibitors, acetazolamide (AZ) and TR1 and GA 15, two aromatic sulfonamides with high affinity for CA Ⅸ, were investigated.The effects of AZ, TR1, and GA15 on cell proliferation and apoptosis were evaluated in CA IX-positive HeLa and 786-O cells and CA IX-negative 786-O/von HippelLindau (VHL) cells.
其他文献
Nutrient restriction is a potent means of extending lifespan and postponing diseases, including cancer, in many animal species.However, little is known about the signaling pathways that coordinate the
It is no doubt that methylation plays an important role in breast cancer development and progression.Tumor suppressor genes are the key targets of hypermethylation in breast cancer and therefore may l
The Tp53 gene encodes at least 12 p53 protein isoforms, due to the presence of an internal promoter in intron-4, additional splice variants of intron-9 and the alternative initiation of translation at
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been implicated in the tumorigenic pathway of renal cell carcinoma (RCC), a common malignant tumor arising from the kidney.RCC occ
Parathyroid disease with hypersecretion of parathyroid hormone and generally also hypercalcemia occurs in primary hyperparathyroidism (pHPT).pHPT is caused by a single benign adenoma in85% of cases an
Nasopharyngeal carcinoma (NPC) is a malignant tumor originating in the squamous epithelium.Elevated DNA methyltransferase 1 (DNMT1) expression was previously detected in NPC tumors indicating that abe
FBXW7 is a general tumor suppressor and its mutations have been found in a variety of human cancers.Particularly, FBXW7 mutations occur in nearly 10-15% of colorectal cancer (CRC), ranking it the four
To identify potential microRNA (miRNA) links between Smad3, a mediator of TGF-β (transforming growth factor-β) signaling, and E-cadherin, we characterized the miRNA profiles of two gastric cancer cell
The transcription factor E2F, the main target of the tumor suppressor RB, plays central roles in activation of growth-promoting genes through physiological inactivation of RB by growth stimulation.E2F
CD44 is a cell-surface glycoprotein, which participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis.However,