【摘 要】
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Parathyroid disease with hypersecretion of parathyroid hormone and generally also hypercalcemia occurs in primary hyperparathyroidism (pHPT).pHPT is caused by a single benign adenoma in85% of cases an
【机 构】
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Department of Surgical Sciences, Uppsala University Sweden
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Parathyroid disease with hypersecretion of parathyroid hormone and generally also hypercalcemia occurs in primary hyperparathyroidism (pHPT).pHPT is caused by a single benign adenoma in85% of cases and parathyroid hyperplasia or multiple adenomas in ~ 15%, and very rarely by parathyroid carcinoma (< 1%).Secondary hyperparathyroidism (sHPT) with multiple parathyroid tumor development is a common complication of renal failure.Somatic inactivation of the MEN 1 or HRPT2 tumor suppressor genes are observed in parathyroid adenomas and carcinomas, respectively.
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