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Aging research was hindered because of the long lifespan of available vertebrates.Annual fishes of Nothobranchius have become a new model organism for aging studies.Resveratrol, a natural plant-derived chemical, prolongs lifespan in many animals.Here we used the wild strain of N.guentheri, which has the mean lifespan of 12 months, to detect the effects of resveratrol on the longevity, cognitive ability and aging-related histological markers.