【摘 要】
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Spermatogonial stem cells (SSCs) , also known as male germline stem cells, are one of the most important stem cell systems throughout the life of male anima
【机 构】
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南京军区福州总医院临床遗传与实验医学科,福州350025
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Spermatogonial stem cells (SSCs) , also known as male germline stem cells, are one of the most important stem cell systems throughout the life of male animals, not only because they are the unique adult stem cells that transmit genetic information to offspring, but also the potential pluripotency that they indicated in recent studies.However, the mechanism of its pluripotency remains poorly understood.In this review, we focused on discussing the approaches for isolation and purification SSCs as well as cultivation and identification SSCs.Based on the published studies, the unlimited potential of SSCs to acquire pluripotency and plasticity under specific culture conditions were discussed as well.Meanwhile, we addressed therapeutic potential and potential future utility of SSCs in both human reproductive and regenerative medicine.Furthermore, SSCs.may also provide new opportunities to study genetic diseases in various cell lineages in the future.
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