【摘 要】
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表皮葡萄球菌(Staphylococcus epidermidis)是一种定植于人体皮肤和粘膜表面的正常菌群.近年的流行病学调查显示,以表皮葡萄球菌为代表的凝固酶阴性葡萄球菌己成为医院获得性感染的重要病原菌.表皮葡萄球菌致病机制主要与形成生物膜有关.转肽酶A(sortase A)普遍存在于革兰氏阳性细菌中,介导细菌的表面蛋白以共价结合的方式锚定在细菌的细胞壁表面.多种革兰氏阳性菌的毒力相关蛋白都是
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表皮葡萄球菌(Staphylococcus epidermidis)是一种定植于人体皮肤和粘膜表面的正常菌群.近年的流行病学调查显示,以表皮葡萄球菌为代表的凝固酶阴性葡萄球菌己成为医院获得性感染的重要病原菌.表皮葡萄球菌致病机制主要与形成生物膜有关.转肽酶A(sortase A)普遍存在于革兰氏阳性细菌中,介导细菌的表面蛋白以共价结合的方式锚定在细菌的细胞壁表面.多种革兰氏阳性菌的毒力相关蛋白都是以这种方式锚定在细菌细胞表面发挥毒性作用的.
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