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  5. FZD7 expression is related to the homeostasis of intraepithelial lymphocytes and the maintenance of

FZD7 expression is related to the homeostasis of intraepithelial lymphocytes and the maintenance of

来源 :The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议) | 被引量 : 0次 | 上传用户：liongliong484
【摘 要】
：
Background and aims Intraepithelial lymphocytes (IELs) residing within the intestinal epithelium are endowed with the ability to safeguard the integrity of the epithelium as well as ward against intes
【作 者】
：
D.Zhao C.W.Cai A.T.Xu S.Jin J.Shen 
【机 构】
：
State Key Laboratory of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shangh
【出 处】
：
The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
【发表日期】
：
2014年5期
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论文部分内容阅读
Background and aims Intraepithelial lymphocytes (IELs) residing within the intestinal epithelium are endowed with the ability to safeguard the integrity of the epithelium as well as ward against intestinal pathogens.Failure of balancing between the thymic (natural) and peripheral (induced) subpopulations together with the misbehavior of those cells may initiate and/or exacerbate inflammatory bowel disease.Previous findings suggested there are abnormal methylations within the FZD7 promoter region, which is a receptor of canonical Wnt signaling pathway.Wnt pathway is known to interact with T lymphocytes possibly via IL-15.We investigate whether methylation of FZD7 promoter can interact with IEL function and cause damage in the intestinal epithelium.
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