LincRNA-p21 feedback enhances P53 activity via interaction with MDM2 function in vascular smooth mus

来源 :2013中国心脏大会(CHC) | 被引量 : 0次 | 上传用户:www6331758
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective To investigate the relationship and molecular mechanism of lincRNA-p21 in the development of atherosclerosis (AS).Methods Firstly,we detected the expression of lincRNA-p21 expression in th aortic plaque of apoE-/- mice fed with high-fat diet and peripheral blood mononuclear cells of clinical coronary disease patients.
其他文献
Background Pulmonary hypertension is a pathophysiologic syndrome with high morality and disability.Pulmonary hypertension is associated with intracellular membrane trafficking in which the protein Sna
会议
Background Spinal cord and vagus nerve stimulation were demonstrated to reduce the incidence of ventricular arrhythmias (VAs), somatic nerve stimulation was reported to improve myocardial ischemia and
会议
Objective We examined the role of renal denervation on the inducibility of AF in dogs with pacing-induced HF.Background Atrial fibrillation (AF) and heart failure (HF) are co mmon interrelated conditi
会议
Purpose In previous studies, it has been shown that recombinant human neuregulin-1 (rhNRG-1) is capable of improving the survival rate in animal models of doxorubicin (DOX)-induced cardiomyopathy
会议
Objective To investigate the effects of sildenafil on the remodeling of pulmonary arterial and TNF-alpha expression in model induced by monocrotaline in pneumonectomized rats.
会议
Objective To investigate transplantation of MSCs in treatment of DCM on the feasibility of TGF-β1, AT1, CYP11B2 and myocardial collagen expression.Method 1.Rate were injected ADR to build DCM model.
会议
Aim Renal ischemia/reperfusion (I/R) injury is a co mmon clinical disease.We have known that NO-signal transduction has an important effect on renal I/R injury.
会议
Rationale Transplantation of stem cells into damaged hearts has had modest success as a treatment for ischemic heart disease.One of the limitations is the poor stem cell survival in the diseased micro
会议
Background In this study we investigate the in vitro pharmacokinetic of nanoporous CREG eluting-stent (CREGES) and evaluate the efficacy and safety of nanoporous CREGES in inhibiting neointima prolife
会议
Background The aim of the present study was to assess the effects of rosuvastatin on contrast-induced nephropathy (CIN) in diabetic nephropathy rats.Methods Male SD rats,using a single intraperitoneal
会议