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Arginine deiminase(ADI)catalyzes the hydrolysis of L-arginine to form citrulline and ammonia.As an anti-tumor enzyme,ADI is being used to treat arginine auxotrophic tumors by depleting the arginine in blood circulationcll.However,ADIs application as anti-cancer drug is hampered by its low activity towards arginine under physiological conditions,mainly due to its low activity at physiologic concentration of arginine(0.10-0.12 mM).