【摘 要】
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Objective: Mesoporous carbon (MC) was as cartier of poorly water-soluble drugs for enhancing the permeation of through Caco-2 cell monolayers membrane and the oral bioavailability.Methods: MC was synt
【机 构】
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Shenyang Pharmaceutical University, 110016, PR China
【出 处】
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2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会
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Objective: Mesoporous carbon (MC) was as cartier of poorly water-soluble drugs for enhancing the permeation of through Caco-2 cell monolayers membrane and the oral bioavailability.Methods: MC was synthesized by a hard template method.The characterization techniques of TEM, N2 adsorption/desorption, DSC, XRD and the in vitro dissolution experiment were used to describe the the drug loading and release behaviors.In vivo pharmacokinetics, uptake and the permeation test were to estimate the oral bioavailability and explore the absorption mechanisms.Results: The dissolution rate of CEL from MC was significantly increased compare with crude CEL.The bioavailability of CEL loaded into MC was higher than that of commercial CEL capsules.Moreover, the permeability rate of CEL through the Caco-2 cell monolayer was enhanced by MC.Conclusion: The bioavailability of CEL loaded into MC was improved.The mechanisms on the bioavailability enhancement of CEL were mainly due to that the permeability rate of CEL through the Caco-2 cell monolayer were enhanced by MC.
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