Combined therapy of Neuropilin-1 positive T cells with low-dose rapamycin prolongs fully MHC-mismatc

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：jonnykang001

【摘要】

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【作者】

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袁清洪善娟金海龙王强李响李州利石炳毅蔡明

【机构】

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解放军第309医院器官移植研究所泌尿外科清华大学医学院免疫学系

【出处】

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中国免疫学会第九届全国免疫学学术大会

【发表日期】

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2014年8期

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Neuropilin-1 (Nrp1) has recently been implicated in the regulation of CD4 T-cell immune responses in experimental autoimmune encephalitis.However, whether Nrp1 plays a role in T cell mediated allograft rejection remains unclear.In this study we for the first time investigate the regulatory effects of Nrp1 +T cells both in vitro and in vivo.We observed that Nrp1+ T cells markedly suppressed the proliferation of alloreactive splenocytes, starting at 1∶4 ratios, with a suppressive property as potent as CD4+CD25+Treg cells (P ＜ 0.05 for Nrpl+ T cells, P ＜ 0.01 for CD4+CD25+ T cells).

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