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Background: To study the impact of μ,κ,and δ opioid receptors on tibial inhibition of bladder overactivity in cats Methods: In α-chloralose anesthetized cats we examined the role of opioid receptor (OR) subtypes (μ,κ,and δ)intibialnerve stimulation (TNS) induced inhibition of bladder overactivity elicited by intravesical infusion of 0.25% acetic acid (AA).