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Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries.plasma perfusion has recently been incorporated as a method of clinical detoxification.The purpose of this study was to estimate the paraquat clearance of plasma perfusion, and observe the effect of plasma perfusion on paraquat concentration in the blood of patients with acute paraquat poisoning.Methods: 21 PQ-poisoned patients admitted to our poisoning center within 24 hours after the ingestion were prospectively enrolled.Continuous plasma perfusion (flow rate 180 ml/min) was performed, with plasma/blood separation at 40 ml/min and routine cartridges change every 3 hours.