A large number of genetic variants associated with human diseases are found in non-coding DNA and may contribute to illness by affecting gene regulation,but mechanistic study of these variants has been hindered by a lack of information of their potential regulatory targets.In order to overcome this limitation,we generate maps of long-range chromatin interactions centered on 19,539 promoters in 27 human cell/tissue types,and use this information to infer putative target genes of candidate cis-regulatory sequences throughout the human genome.In addition to known enhancer-promoter interactions,we also confirm widespread promoter-promoter interactions and obtain evidence suggesting enhancer-like function for many promoter regions.These promoter-centered chromatin interaction maps corroborate target genes of genetic variants defined in previous genome-wide association studies,predict new target genes of many disease-associated genetic variants,and contribute novel insights into a broad spectrum of human traits and diseases.