【摘 要】
：
Accumulating evidences suggest that tumors are composed of a heterogeneous cell population with a small subset of cancer stem cells (CSCs) that sustain tumor formation and growth.Recently, there have
【机 构】
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Director of Yonsei Pancreatobiliary Cancer Clinic Yonsei University College of Medicine Korea
【出 处】
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BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Accumulating evidences suggest that tumors are composed of a heterogeneous cell population with a small subset of cancer stem cells (CSCs) that sustain tumor formation and growth.Recently, there have been efforts to explain drug resistance of cancer cells based on the concept of CSCs having an intrinsic detoxifying mechanism.In the present study, to investigate the role of CSCs in acquiring chemoresistance in pancreatic cancer, gemcitabine-resistant cells were established by exposure to serially escalated doses ofgemcitabine in HPAC and CFPAC-1 cells.Gemcitabine-resistant cells were more tumorigenic in vitro and in vivo, and had greater sphere-forming activity than parental cells.After high-dose gemcitabine treatment to eliminate most of the cells, CD44+ cells proliferated and reconstituted the population of resistant cells.CD44+CD24+ESA+ cells remained as a small subset in the resistant cell population.
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