【摘 要】
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A new class of non-coding RNAs,designated long non-coding RNAs(lncRNAs),was recently found to be frequently deregulated in various diseases.Although previous data suggested that lncRNAs are likely to
【机 构】
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Department of Medica1 Genetics,Second Military Medical University,Shanghai,200433,China
【出 处】
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中华医学会2012年医学遗传学年会暨全国第十一次医学遗传学学术会议
论文部分内容阅读
A new class of non-coding RNAs,designated long non-coding RNAs(lncRNAs),was recently found to be frequently deregulated in various diseases.Although previous data suggested that lncRNAs are likely to have biological effects,this possibility needs to be confirmed by specific hypothesis-driven studies.Understanding the precise molecular mechanisms by which lncRNAs function in various diseases will be critical for exploring new potential strategies for early diagnosis and therapy.Over the past several years,multiple studies have demonstrated that nearly every step in the life cycle of a gene can be regulated by lncRNAs.Nevertheless,the regulation of lncRNAs in cancer is not well-studied.Previous research demonstrated that numerous lncRNAs are key components of the p53-dependent transcriptional pathway.Another interesting study determined that lncRNA expression can be controlled by epigenetic mechanisms such as histone modifications.
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