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Acute lung injury is accompanied with a significant elevation in the levels of pro-inflammatory cytokines and leukocyte infiltration in the lungs.Also,acute lung injury is a severe illness with high rate mortality.Therefore,we used HMGB1A and Heparin which have anti-inflammatory activities.High mobility group box 1 (HMGB1A) is an abundant nuclear and cytoplasmic protein.Besides,HMGB 1 is released from necrotic cells as well as macrophages and pro-inflammatory cytokine.Here,we used HMGB1 a box (HMGB1A) as an antagonist fragment of HMGB1.