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  5. Downregulation of PLK1 inhibits tumor call metastasis through degradation of β-catenin in esophageal

Downregulation of PLK1 inhibits tumor call metastasis through degradation of β-catenin in esophageal

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：zhengjjing
【摘 要】
：
Aim: PLK1 is a serine/threonine kinase that regulates cell cycle and is overexpressed in many tumors.Our study aimed to investigate the biological functions and mechanisms of PLK1 in metastasis of eso
【作 者】
：
Xiao-ying LIU Wen-jing YU Li-mei CHEN Zhi-qin GAO Wei-guo FENG Chang-qing DU Chun-ling ZHAO 
【机 构】
：
Department Of Cell Biology,Weifang Medical University,Weifang 261042,China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
PLK Esophageal squamous cell carcinoma RNA interference EMT β-catenin 
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Aim: PLK1 is a serine/threonine kinase that regulates cell cycle and is overexpressed in many tumors.Our study aimed to investigate the biological functions and mechanisms of PLK1 in metastasis of esophageal squamous cell carcinoma (ESCC).Methods: The ESCC cell overexpressed PLK1 was screened by RT-PCR and Western blot.The effective PLK1siRNA fragment was screened by Western blot.
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