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  5. Effect of S003 on sulfur mustard-induced cutaneous Injuries in the mouse ear vesicant model and huma

Effect of S003 on sulfur mustard-induced cutaneous Injuries in the mouse ear vesicant model and huma

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：nizhongyu
【摘 要】
：
Aim: Sulfur mustard (SM) can cause DNA damage and the activation of poly(ADPribose)polymerase (PARP).PARP inhibitor has been reported some protective effects in SM skin injury in vivo and in vitro.S00
【作 者】
：
Feng LIU Yong-xiang ZHANG Ning JIANG Zhi-yong XIAO Xin-bo ZHOU Jun-ping CHENG Yi-zhou MEI Xiao-rui ZHANG Pan ZHENG Wen-xia ZHOU 
【机 构】
：
Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
Sulfur mustard PARP S003 apoptosis ear edema 
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Aim: Sulfur mustard (SM) can cause DNA damage and the activation of poly(ADPribose)polymerase (PARP).PARP inhibitor has been reported some protective effects in SM skin injury in vivo and in vitro.S003 is a PARP inhibitor synthesized by our institute.The aim of our study is to observe the effect of S003 in SM treated HaCaT cells and in SM induced mouse ear vesicant model (MEVM).
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