【摘 要】
：
In recent years, the World Health Organization has developed a fracture risk assessment tool-FRAX.Using easily obtainable clinical risk factors with or without femoral neck BMD, FRAX provides models f
【机 构】
：
Institute of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University
【出 处】
：
中华医学会第五次中青年骨质疏松和骨矿盐疾病学术会议
论文部分内容阅读
In recent years, the World Health Organization has developed a fracture risk assessment tool-FRAX.Using easily obtainable clinical risk factors with or without femoral neck BMD, FRAX provides models for assessing the ten-year probability of a major osteoporotic fracture (hip, clinical spine, humerus or wrist fracture) and a hip fracture, and determining possible thresholds for therapeutic intervention.
其他文献
背景 传统认为,维生素D参与调节钙平衡,近来越来越多研究表达,其在免疫调节中发挥重要作用.类风湿关节炎病人(RA)中普遍存在维生素D缺乏,血清维生素D水平与RA疾病活动度相关,有研究表明补充维生素D能缓解RA患者晨僵及疼痛状态.核因子κB受体活化因子配体(RANKL)是近20年来发现的最重要的调节破骨细胞分化激活的因子,在RA骨侵蚀中发挥重要作用.
Purpose Angiotensin Ⅱ(Ang Ⅱ) significantly induced the expression of receptor activator of NF-κ B ligand (RANKL) in osteoblasts, leading to the formation of osteoclasts.Monocyte chemoattractant protei
目的 研究低频脉冲超声对于抑制兔股骨远端假体周围骨溶解进程的作用.方法 我们通过经髌侧入路暴露髌股关节、钻孔建立骨隧道、插入钢条同时注射聚乙烯颗粒的方法,构建兔股骨远端假体周围骨溶解模型(同第一部分).实验分成两组,取16只新西兰大白兔.
Purpose Angiotensin Ⅱ(Ang Ⅱ) accelerates osteoporosis by activating osteoclasts via receptor activator of nuclear factor-κ B ligand(RANKL) induction.However, the precise mechanism of Ang Ⅱ induction R
目的 探讨不同途径摄取糖皮质激素对大鼠骨髓基质干细胞(BMSCs)生物活性的影响.方法 48只5月龄SD大鼠随机分成正常组、口服激素组、肌注激素组,每组16只.分别于应用激素9和12周,每组取8只麻醉后,取左股骨检测骨密度(BMD),第12周结束后取右股骨,无菌下取骨髓培养BMSCs,MTT检测细胞增殖,AKP活性检测成骨能力,油红O染色观察成脂能力.
目的 蛋白组学研究表明,S 100A4蛋白和MC3T3-E1细胞的成骨分化有关.本研究探讨了S100A4钙结合蛋白在大鼠卵巢切除骨质疏松模型中各时间段表达情况.方法 选择健康4周龄的雌性SD大鼠32只,体重约为100±20g,随机分成实验组和对照组.实验组(24只)行双侧卵巢切除术(OVX组),对照组(12只)行卵巢周围脂肪切除的假手术组(Sham组).术后给予青霉素肌注3天及正常饲养.
Objective To explore the treatment of 99Tc-MDP on rats with osteoporosis induced by dexamethasone.Methods 30 of the 12-week-old female Wistar rats were randomly divided into three groups, control grou
目的 质子泵抑制剂(proton pump inhibitors,PPIs)被广泛应用于治疗各种酸相关疾病,它是通过阻断胃壁细胞上的质子泵,即H+/K+-ATP酶来发挥作用的.但是近年来许多研究报道,长期、大剂量应用质子泵抑制剂会增加人群髋骨骨折发生的危险.而我们主要研究不同剂量的质子泵抑制剂在不同时间点对雄性SD大鼠的影响.
Purpose Glucocorticoids(GCs) treatment frequently causes osteoporosis, but currently the precise mechanism in the pathogenesis of glucocorticoid-induced osteoporosis(GIOP) is still not fully elucidate
目的 研究TGF-β RI阻断剂SB-505124对软骨细胞增殖、分化及细胞外基质的影响与机制.方法 利用Western blot检测不同浓度的SB-505124处理后,前软骨细胞系ATDC5中p-Smad2/3的变化.MTT法检测SB-505124处理对ATDC5细胞生长、增殖的影响及时间、浓度依赖性效应.