Objective: This study aimed to explore the function changes of related brain region in adults with nonsyndrome cleft lip and palate(NSCL/P),by using task-based fMRI,which help to select effective rehabilitation treatments.Methods:Two groups,24 adults after palatoplasty with speech training and 24 healthy young volunteers as age-matched and sex-matched controls.Brain activation during speech task and behavioral data were recorded by using functional MRI,which was scanned from cranial vault to foramina magnum.High resolution 3DT1,3DT2,DKI,and speech task based fMRI weighted images were acquired.Blocks design was used to objective brain activation linked to the speech task.Then,all these data were processed with VBM,DPARSF software.in statistical parametric mapping software(SPM12).These results in conjuction with images from each group were put into second-level one-sample t-tests to yield group-level activation Results:Patients with NSCL/P responded to the target significantly more slowly compared with the controls,whereas no significant difference in accuracy was found between the groups.Brain activation had similar patterns between groups.Brocas area,Wernickes area,motor areas,somatosensory areas,and insula in both hemispheres,the dorso lateral prefrontal cortex and the ventrolateral prefrontal cortex in the right hemisphere were activated in both groups,with no statistically significant difference.Furthermore,the two sample t-test showed that the hippocampus in the left hemisphere was activated significantly in patients with NSCL/P compared with the controls.Conclusion:Adults with NSCL/P have abnormal brain structure,potentially due to abnormal language development caused by structural articulation disorder.the hippocampus might be involved in the language-related neural circuit in patients with NSCL/P and play a role on pronunciation retrieval to help patients with NSCL/P to complete the pronunciation effectively.