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5. Synthesis and anti-proliferative activity evaluation of maleopimaric N-arylimides atropisomers

Synthesis and anti-proliferative activity evaluation of maleopimaric N-arylimides atropisomers

来源 :全国药物化学学术会议暨第四届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：hotmail124

【摘 要】

：

Atropisomerism of pharmaceutical compounds is a challenging area for drug discovery programs [1].Recently,in our laboratory work,maleopimaric N-naphthylimide was found exhibited anti-proliferative act

【作 者】

：

Yao Gui-yang Heng-shan Wang Ye Man-yi Huang Ri-zhen Liao Zhi-Xin 

【机 构】

：

Department of Pharmaceutical Engineering,School of Chemistry and Chemical Engineering,Southeast Univ

【出 处】

：

全国药物化学学术会议暨第四届中英药物化学学术会议

【发表日期】

：

2013年11期

【关键词】

：

Maleopimaric acid Diimides Atropisomers Cytotoxicity Apoptosis 

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　　Atropisomerism of pharmaceutical compounds is a challenging area for drug discovery programs [1].Recently,in our laboratory work,maleopimaric N-naphthylimide was found exhibited anti-proliferative activity and existed atropisomers in solution at room temperature.

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