In order to prepare dry powder inhalation for pulmonary delivery of siRNA for lung cancer therapy, the effect of Anti-EGFR mAb modification and cationization of survivin-siRNA loaded liposome on the cellular uptake of A549/DDP was investigated.The physicochemical properties and cytotoxicity of carriers as well as the cellular uptake and apoptosis were observed, too.In results, as a novel cationization agent, staramine and DSPE-PEG2000-Mal were successfully synthesized with relative high purity as 87.0 % and 86.2 %, respectively.